Nanotechnology offers An array of possibilities to contribute to biology. Below I will existing examples the place nanofabrication – the opportunity to make confined structures with Proportions at will – is applied to examine the biophysics of one molecules and cells. I'll present some illustrations from our lab:
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‘It absolutely was basically a make a difference of picking up a reserve on mobile biology and starting to browse. I'd come from a environment of extremely-higher vacuums, cryostats and quantum phenomena, and now I had been Performing at area temperature with molecular biology kits.
Deposition and atomic pressure microscopy of specific phthalocyanine polymers among nanofabricated electrodes
De sterke polarisatie in de discussie rond schepping/evolutie en meer algemeen rond geloof/wetenschap lijkt helaas geen eind te kennen. Toch is er wel degelijk een heilzame middenweg, maar deze krijgt above het algemeen weinig aandacht. Dit boek kan hier wellicht verandering in brengen. Wie de geschiedenis van de relatie tussen geloof en wetenschap in duikt, komt tot verrassende inzichten. De moderne mens leeft satisfied veel stereotypen die historisch niet verantwoord blijken te zijn. Afgezaagde typeringen als ‘Vroeger dachten we dat de
SMC complexes can move physical roadblocks larger than their ring sizing, indicating a nontopological system for DNA loop extrusion
Many associated developments followed, exactly where our group proven diverse transistor variants for instance one-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled various transistors into compact evidence-of-basic principle Digital circuits.
Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation
‘Indeed, I have an understanding of folks were being shocked at enough time. At the conclusion of the nineties, when I was in my forties, I had been Professor of Molecular Electronics and I've to admit that it experienced turn https://www.ceesdekker.net into a bit bored, I didn’t find out A great deal any more. The sector went additional into the application side, how you could possibly combine nanotubes into electronic circuits.
Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding as being the action-creating course of action
‘The concept that There may be this kind of thing like a starting, a giant bang, is already an interesting signpost to take into account that there was a creator. But extra generally, and on the basis of pure rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview is often a naturalistic worldview: essentially, you'll find only atoms and normal forces that we could evaluate.
‘That issues the artificial cell, as Portion of the Dutch BaSyC initiative. Craig Venter appeared leading-down in Those people days and determined about 5 hundred genes which are minimally expected to get a operating mobile. We want to seem base-up: how do we transfer from the couple molecules to a complete biological process?
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
Strong-state nanopores have confirmed for being a incredibly adaptable probe for solitary-molecule Examination of DNA. I will describe a number of our modern results – especially DNA knots – and also our attempts to increase the capabilities of strong-state nanopores even further, in the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.